M8-B Hydrochloride
M8-B Hydrochloride is a selective transient receptor potential melastatin-8 (TRPM8) channel antagonist.M8 B, a TRPM8 antagonist, can reduce body temperature.M8 B decreased the body temperature of rat pups and increased the latency to the first febrile seizure, implying a significant protective effect. It also induced a significant anticonvulsant effect in PTZ but not electroshock induced convulsions. M8 B showed anticonvulsant effects in both febrile and PTZ induced seizures. M8 B had a hypothermic effect with significant protective effects on febrile and PTZ induced seizures.
Product Specifications
CAS Number
883976-12-3
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 250 mg/mL (577.42 mM)
Smiles
Cl.COc1cc (CN (CCN) C (=O) c2cccs2) ccc1OCc1ccccc1
Molecular Formula
C22H25ClN2O3S?
Molecular Weight
432.96
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
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