M8-B Hydrochloride

M8-B Hydrochloride is a selective transient receptor potential melastatin-8 (TRPM8) channel antagonist.M8 B, a TRPM8 antagonist, can reduce body temperature.M8 B decreased the body temperature of rat pups and increased the latency to the first febrile seizure, implying a significant protective effect. It also induced a significant anticonvulsant effect in PTZ but not electroshock induced convulsions. M8 B showed anticonvulsant effects in both febrile and PTZ induced seizures. M8 B had a hypothermic effect with significant protective effects on febrile and PTZ induced seizures.