Sertindole
Sertindole is an atypical antipsychotic that binds to dopamine D2 receptors and the serotonin (5-HT) receptor subtypes 5-HT1D 5-HT2A and 5-HT2C (Kds = 2.7 20 0.14 and 6 nM respectively) (In Vitro) :Sertindole (0-100 μM; 48 h) attenuates proliferation of breast cancer cells.Sertindole (0.8-27.6 μM; 48 h) inhibits proliferation toward many cancers in vitro.Sertindole (5 μΜ and 10 μΜ; 24 h) attenuates migration of breast cancer cells. (In Vivo) :Sertindole (oral gavage; 10 mg/kg; once daily; 12 d) shows anti-tumor activity in vivo.
Product Specifications
CAS Number
106516-24-9
Product Name Alternative
Lu 23-174
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
DMSO:50 mg/mL (113.39 mM)
Smiles
Fc1ccc (cc1) -n1cc (C2CCN (CCN3CCNC3=O) CC2) c2cc (Cl) ccc12
Molecular Formula
C24H26ClFN4O
Molecular Weight
440.94
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
1-[2-[4-[5-chloro-1- (4-fluorophenyl) indol-3-yl]piperidin-1-yl]ethyl]imidazolidin-2-one
Available Sizes
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