Imeglimin hydrochloride
Imeglimin hydrochloride prevents human endothelial cell death by inhibiting mitochondrial permeability transition without inhibiting mitochondrial respiration. (In Vitro) :Preincubation with Imeglimin (10 mM for 4 h or 100 μM for 24 h) also fully prevented tert-butylhydroperoxide (tBH) -induced cell death. (In Vivo) :Imeglimin (200 mg/kg b.i.d. by oral gavage during the last 6 weeks of HFHSD feeding) significantly decreases hyperglycemia, and restores normal glucose tolerance.
Product Specifications
CAS Number
775351-61-6
Product Name Alternative
EMD 387008 hydrochloride
Purity
>98% (HPLC)
Solubility
DMSO:25 mg/mL (130.44 mM)
Smiles
C[C@@H]1N=C (N) NC (N (C) C) =N1.Cl
Molecular Formula
C6H14ClN5
Molecular Weight
191.66
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
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