(S, R, S) -AHPC-Me hydrochloride
(S, R, S) -AHPC-Me hydrochloride can be used to synthesize ARV-771, a von Hippel-Landau (VHL) E3 ligase-based BET PROTAC degrader. ARV-771 potently degrades BET protein in castration-resistant prostate cancer (CRPC) cells with a DC50 <1 nM. (S, R, S) -AHPC-Me hydrochloride (VHL ligand 2 hydrochloride) is the (S, R, S) -AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein.
Product Specifications
CAS Number
1948273-03-7
Product Name Alternative
VHL ligand 2 hydrochloride, E3 ligase Ligand 1
Purity
>98% (HPLC)
Solubility
DMSO:62 mg/mL (128.88 mM)
Smiles
Cl.C[C@H] (NC (=O) [C@@H]1C[C@@H] (O) CN1C (=O) [C@@H] (N) C (C) (C) C) c1ccc (cc1) -c1scnc1C
Molecular Formula
C23H33ClN4O3S
Molecular Weight
481.05
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Available Sizes
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