TMN355
TMN355 is a potent chemical inhibitor of cyclophilin A and reduces foam cell formation and cytokine secretion, and is used for atherosclerosis. Silencing cyclophilin A in THP-1 cells and human monocytes using siRNA or chemical inhibitor, TMN355 resulted in decrease in lipid uptake by 65-75% even after exposure to oxidized LDL. The expression of scavenger receptors expressed during differentiation process, CD36 and LOX-1 were decreased (p < 0.0001) . Levels of extracellular cyclophilin A and other inflammatory cytokines such as TNF-α and MCP-1also significantly reduced. TMN 355 (0.5-10 μM; 3-9 hours) results in 75.9% reduction of cyclophilin A protein expression. And cyclophilin A after 6 h of activation inhibited by TMN 355 (1 μM) .
Product Specifications
CAS Number
1186372-20-2
Purity
>98% (HPLC)
Solubility
DMSO:31.25 mg/mL (82.06 mM; Need ultrasonic)
Smiles
O=C (NC (NC1C2=C (C3=C1C=CC=C3) C=CC=C2) =O) C4=C (F) C=CC=C4Cl
Molecular Formula
C21H14ClFN2O2
Molecular Weight
380.8
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Available Sizes
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