Mivacurium chloride

Mivacurium chloride is a non-depolarising, rapid neuromuscular blocker of short duration, used therefore as anesthetic, to provide skeletal muscle relaxation in minor surgical operations, in emergency surgical procedures of short to intermediate duration and during intubation of the trachea. (In Vitro) :Mivacurium induces LAD2 cell degranulation in a dose-dependent manner. Mivacurium stimulates intracellular Ca2+ influx in MRGPRX2-HEK293 cells but not in NC-HEK293 cells. Mivacurium induces the release of only low levels of mediators in LAD2 cells transfected with MRGPRX2-targeted small interfering siRNA. (In Vivo) :Mivacurium causes pseudo-allergic reactions in C57 wild-type mice by inducing mast cells to release histamine and a decrease in body temperature.Mivacurium is rapidly hydrolyzed in the plasma and has a short duration of action (< 10 min) . Mivacurium has many advantages, such as a rapid effect, nonneurological toxicity and a lack of heart rate alteration.