Cinobufotalin
Cinobufotalin is a main cardiac toxin in toad, it is a novel anti-HCC agent, it induces growth inhibition and apoptosis in cultured HCC cells through ceramide production. Cinobufotalin is also an effective reversal agent for the multidrug resistance of tumors, it can reverse the adriamycin-resistance in Raji/ADR cells and the expression of P-gp and MRP-1 proteins. Cinobufotalin can promote the dendritic cells (DCs) derived from peripheral blood of patients with chronic hepatitis B to mature and effectively enhance its (the DCs') capabilities, therefore the treatment of cinobufotalin may potentiate the antiviral immunity of the patients with chronic hepatitis B (CHB) .
Product Specifications
CAS Number
1108-68-5
Purity
>98% (HPLC)
Solubility
DMSO:35 mg/mL (76.33 mM)
Smiles
C[C@] ([C@@H] (C (C=C1) =COC1=O) [C@H]2OC (C) =O) (CC[C@@]3 ([H]) [C@@]4 ([H]) CC[C@@]5 (O) [C@@]3 (CC[C@H] (O) C5) C) [C@@]64[C@@H]2O6
Molecular Formula
C26H34O7
Molecular Weight
458.54
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
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