Topovale
Topovale is a potent inhibitor of topoisomerase I. Topovale inhibits hypoxia-mediated accumulation of hypoxia-inducible factor-1alpha. Topovale exhibited low nM cytotoxicity against a panel of cancer cells. Topovale cytotoxicity as well as Topovale-induced apoptosis was reduced > 100-fold in CPT-resistant topoisomerase I (TOP1) -deficient P388/CPT45 cells as compared with P388 cells.
Product Specifications
CAS Number
500214-53-9
Product Name Alternative
Topoval | ARC 111 | ARC111 | ARC-111
Purity
>98% (HPLC)
Solubility
DMSO:10 mM
Smiles
COC1=C (OC) C=C (C (N (CCN (C) C) C2=C3C=NC4=C2C=C (OCO5) C5=C4) =O) C3=C1
Molecular Formula
C23H23N3O5
Molecular Weight
421.45
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
MBS6290770-01 0.2 mL
DAGLB, ID (DAGLB, Sn1-specific diacylglycerol lipase beta, KCCR13L) (PE)
Sign In for Pricing
View Details MBS6290770-02 5x 0.2 mL
DAGLB, ID (DAGLB, Sn1-specific diacylglycerol lipase beta, KCCR13L) (PE)
Sign In for Pricing
View Details 
bs-15312R-BF350 100 µL
C9orf135 Polyclonal Antibody, AbBy Fluor™ 350 Conjugated
Sign In for Pricing
View Details