AES-350
AES-350 is a potent and orally active HDAC6 inhibitor (IC50 and a Ki of 0.0244 μM and 0.035 μM, respectively) . It is also against HDAC-3, -8, and -11 in an enzymatic activity assay with IC50 values of 0.187 μM, 0.245 μM, and >1μM, respectively. AES-350 triggers apoptosis in AML cells through HDAC inhibition and can be used for acute myeloid leukemia (AML) research.
Product Specifications
CAS Number
847249-57-4
Purity
>98% (HPLC)
Solubility
DMSO:100 mg/mL (320.14 mM; Need ultrasonic)
Smiles
CC (C) (C) C1=CC=C (C (NC2=CC=C (C (NO) =O) C=C2) =O) C=C1
Molecular Formula
C18H20N2O3
Molecular Weight
312.36
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
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