PF00835231 (SARS-CoV-2 inhibitor 5h)
PF00835231 (SARS-CoV-2 inhibitor 5h) is areversible-covalent inhibitor of SARS-CoV-2 main protease (Mpro) with EC50 of 4.2 μM. Compound 5h blocks the infectivity and cytopathicity of the virus with high potency and without any detectable cytotoxicity even at 200 μM.PF-00835231 is a potent inhibitor of CoV-2 3CLpro with IC50 of 4 nM and shows suitable pharmaceutical properties to warrant further development as an intravenous treatment for COVID-19.
Product Specifications
CAS Number
870153-29-0
Smiles
COc1c2c ([nH]c (c2) C (N[C@H] (C (N[C@H] (C (c2sc3c (cccc3) n2) =O) C[C@H]2C (=O) NCC2) =O) CC (C) C) =O) ccc1
Molecular Formula
C30H33N5O5S
Molecular Weight
575.68
Notes
For research use only.
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