5-Fluoro-UTP
5-Fluoro-UTP
Product Specifications
CAS Number
3828-96-4
Product Name Alternative
(5F-UTP), 5-Fluoro-uridine-5'-triphosphate, Sodium salt
Concentration
100 mM-110 mM
Purity
≥ 95% (HPLC)
Form
Solution in water; Color: colorless to slightly yellow; pH: 7.5 ± 0.5
Smiles
OP (=O) (O) OP (=O) (OP (=O) (OC[C@@H]1[C@H] ([C@@H] (O) [C@H] (n2cc (F) c (=O) [nH]c2=O) O1) O) O) O
Molecular Formula
C9H14N2O15P3F
Molecular Weight
Theoretical MW: 502.13 g/mol (free acid) ; Detected MW: 501.96 g/mol (free acid)
References & Citations
Susanta Chatterjee 1, Parisa Naeli 1, Okan Onar 1 2, Nicole Simms 3, Aitor Garzia 4, Angela Hackett 1, Kelsey Coyle 1, Patric Harris Snell 1, Tom McGirr 1, Tanvi Nitin Sawant 1, Kexin Dang 3, Zornitsa Vasileva Stoichkova 3, Yumna Azam 1, Mark P Saunders 3, Michael Braun 3, Tommy Alain 5, Thomas Tuschl 4, Simon S McDade 1, Daniel B Longley 1, Christos G Gkogkas 6, Colin Adrain 1, John R P Knight 3, Seyed Mehdi Jafarnejad 1 Ribosome Quality Control mitigates the cytotoxicity of ribosome collisions induced by 5-Fluorouracil Nucleic Acids Res, (2024)
Pubmed id
39351862
Storage Conditions
Store at -20 °C. Short term exposure (up to 1 week cumulative) to ambient temperature possible.
Notes
For research use only.
Applications Notes
Inhibition of viral application; Mutagenic activity; Conformational studies (NMR-NOE) of HIV-2 TAR-RNA; Use as NMR-label (F) ; X-ray of viral RNA polymerase. Spectroscopic Propertie: λmax 267 nm, ε 10.0 L mmol-1 cm-1 (Tris-HCl, pH 7.5) .
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