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5-Fluoro-UTP

5-Fluoro-UTP

Product Specifications

CAS Number

3828-96-4

Product Name Alternative

(5F-UTP), 5-Fluoro-uridine-5'-triphosphate, Sodium salt

Concentration

100 mM-110 mM

Purity

≥ 95% (HPLC)

Form

Solution in water; Color: colorless to slightly yellow; pH: 7.5 ± 0.5

Smiles

OP (=O) (O) OP (=O) (OP (=O) (OC[C@@H]1[C@H] ([C@@H] (O) [C@H] (n2cc (F) c (=O) [nH]c2=O) O1) O) O) O

Molecular Formula

C9H14N2O15P3F

Molecular Weight

Theoretical MW: 502.13 g/mol (free acid) ; Detected MW: 501.96 g/mol (free acid)

References & Citations

Susanta Chatterjee 1, Parisa Naeli 1, Okan Onar 1 2, Nicole Simms 3, Aitor Garzia 4, Angela Hackett 1, Kelsey Coyle 1, Patric Harris Snell 1, Tom McGirr 1, Tanvi Nitin Sawant 1, Kexin Dang 3, Zornitsa Vasileva Stoichkova 3, Yumna Azam 1, Mark P Saunders 3, Michael Braun 3, Tommy Alain 5, Thomas Tuschl 4, Simon S McDade 1, Daniel B Longley 1, Christos G Gkogkas 6, Colin Adrain 1, John R P Knight 3, Seyed Mehdi Jafarnejad 1 Ribosome Quality Control mitigates the cytotoxicity of ribosome collisions induced by 5-Fluorouracil Nucleic Acids Res, (2024)

Pubmed id

39351862

Storage Conditions

Store at -20 °C. Short term exposure (up to 1 week cumulative) to ambient temperature possible.

Notes

For research use only.

Applications Notes

Inhibition of viral application; Mutagenic activity; Conformational studies (NMR-NOE) of HIV-2 TAR-RNA; Use as NMR-label (F) ; X-ray of viral RNA polymerase. Spectroscopic Propertie: λmax 267 nm, ε 10.0 L mmol-1 cm-1 (Tris-HCl, pH 7.5) .

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