TCS PrP Inhibitor 13

TCS PrP Inhibitor 13, an antiprion agent, is a cellular prion protein (PrPC) inhibitor. TCS PrP Inhibitor 13, as a protease-resistant form of prion protein (PrP-res) accumulation inhibitor, shows an IC50 value of 3 nM in both ScN2a and F3 cell lines. TCS PrP Inhibitor 13 induces Schwannoma cells apoptosis[1].

Product Specifications

CAS Number

[34320-83-7]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

Apoptosis

Type

Reference compound

Related Pathways

Apoptosis

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/tcs-prp-inhibitor-13.html

Concentration

10mM

Purity

99.72

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1CC(C2=CC=C([N+]([O-])=O)C=C2)=NN1C3=CC=CC=C3

Molecular Formula

C15H11N3O3

Molecular Weight

281.27

Precautions

H302, H315, H319

References & Citations

[1]Kimata A, et al. New series of antiprion compounds: pyrazolone derivatives have the potent activity of inhibiting protease-resistant prion protein accumulation [published correction appears in J Med Chem. 2008 Mar 13;51 (5) :1503]. J Med Chem. 2007;50 (21) :5053-5056.|[2]Provenzano L, et al. Cellular prion protein (PrPC) in the development of Merlin-deficient tumours. Oncogene. 2017;36 (44) :6132-6142.