Trabedersen
Trabedersen (AP 12009) is an antisense oligodeoxynucleotide that specifically inhibits TGF-β2 (TGF-beta/Smad) . Trabedersen can be used for the study of malignant brain tumors and other solid tumors overexpressing TGF-β2, such as those of the skin, pancreas and colon[1][2].
Product Specifications
CAS Number
925681-61-4
Product Name Alternative
AP 12009
UNSPSC
12352208
Target
TGF-beta/Smad
Type
Oligonucleotides
Related Pathways
Stem Cell/Wnt; TGF-beta/Smad
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/trabedersen.html
Purity
90.45
Solubility
H2O : 100 mg/mL (ultrasonic)
Smiles
[Trabedersen]
Molecular Formula
C177H225N60O94P17S17
Molecular Weight
5768.70
References & Citations
[1]Luc Vallières. Trabedersen, a TGFbeta2-specific antisense oligonucleotide for the treatment of malignant gliomas and other tumors overexpressing TGFbeta2. IDrugs. 2009 Jul;12 (7) :445-53.|[2]Karl-Hermann Schlingensiepen, et al. Transforming growth factor-beta 2 gene silencing with trabedersen (AP 12009) in pancreatic cancer. Cancer Sci. 2011 Jun;102 (6) :1193-200.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Oligonucleotides
Clinical Information
Phase 3
Available Sizes
Frequently Asked Questions
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