L-685,458
L685458 is a potent and selective γ -secretase inhibitor (IC50 = 17 nM) that displays > 50-fold selectivity over a range of aspartyl, serine and cysteine proteases. L685458 also exhibits equal potency for inhibition of A β 40 and A β 42 peptides (IC50 values are 48 and 67 nM respectively in human neuroblastoma cells) . Also regulates CXCR4 and VEGFR2 expression through inhibition of Notch signaling in vitro.
Product Specifications
CAS Number
292632-98-5
Product Name Alternative
L685458 | L-685458 | L 685458
Purity
>98% (HPLC)
Solubility
DMSO : ≥ 31 mg/mL; 46.07 mM
Smiles
CC (C) C[C@H] (NC (=O) [C@@H] (C[C@@H] (O) [C@H] (Cc1ccccc1) NC (=O) OC (C) (C) C) Cc1ccccc1) C (=O) N[C@@H] (Cc1ccccc1) C (N) =O
Molecular Formula
C39H52N4O6
Molecular Weight
672.85
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Tert-butyl ((2S,3R,5R) -6- (((S) -1- (((S) -1-amino-1-oxo-3-phenylpropan-2-yl) amino) -4-methyl-1-oxopentan-2-yl) amino) -5-benzyl-3-hydroxy-6-oxo-1-phenylhexan-2-yl) carbamate.
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