What is the catalog number for L-685,458?

The catalog number for L-685,458 is orb1222403.

What sizes are available for L-685,458?

L-685,458 is available in the following size(s): 200 mg, 500 mg, 1 g, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg.

How many pack sizes does L-685,458 come in?

L-685,458 is available in 8 different pack sizes.

Is L-685,458 in stock?

L-685,458 is currently made to order / not held in immediate stock. Contact us for lead time.

L-685,458

L685458 is a potent and selective γ -secretase inhibitor (IC50 = 17 nM) that displays > 50-fold selectivity over a range of aspartyl, serine and cysteine proteases. L685458 also exhibits equal potency for inhibition of A β 40 and A β 42 peptides (IC50 values are 48 and 67 nM respectively in human neuroblastoma cells) . Also regulates CXCR4 and VEGFR2 expression through inhibition of Notch signaling in vitro.

Product Specifications

CAS Number

292632-98-5

Product Name Alternative

L685458 | L-685458 | L 685458

Purity

>98% (HPLC)

Solubility

DMSO : ≥ 31 mg/mL; 46.07 mM

Smiles

CC (C) C[C@H] (NC (=O) [C@@H] (C[C@@H] (O) [C@H] (Cc1ccccc1) NC (=O) OC (C) (C) C) Cc1ccccc1) C (=O) N[C@@H] (Cc1ccccc1) C (N) =O

Molecular Formula

C39H52N4O6

Molecular Weight

672.85

Storage Conditions

Storage temperature: -20°C. Stability: ≥ 2 years

Notes

For research use only.

Other Product Names

Tert-butyl ((2S,3R,5R) -6- (((S) -1- (((S) -1-amino-1-oxo-3-phenylpropan-2-yl) amino) -4-methyl-1-oxopentan-2-yl) amino) -5-benzyl-3-hydroxy-6-oxo-1-phenylhexan-2-yl) carbamate.