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Rigosertib

Rigosertib is a selective and non-ATP-competitive inhibitor of PLK1 (IC50: 9 nM) . Rigosertib is a multi-kinase inhibitor and a selective anti-cancer agent, which induces apoptosis by inhibition of the PI3 kinase/Akt pathway, promotes the phosphorylation of histone H2AX and induces G2/M arrest in the cell cycle.

Product Specifications

CAS Number

592542-59-1

Product Name Alternative

ON-01910

Purity

>98% (HPLC)

Solubility

DMSO:75 mg/mL (166.12 mM; Need ultrasonic)

Smiles

COC1=C (C=C (C=C1) CS (=O) (=O) /C=C/C2=C (C=C (C=C2OC) OC) OC) NCC (=O) O

Molecular Formula

C21H25NO8S

Molecular Weight

451.49

Storage Conditions

Storage temperature: -20°C. Stability: ≥ 2 years

Notes

For research use only.

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