CIGB-552 TFA

CIGB-552 TFA is a cell-penetrating peptide with antitumor properties, exhibiting an IC50 of 23 μM in H460 cells. It enhances COMMD1 protein levels and significantly inhibits the NF-κB signaling pathway. Additionally, CIGB-552 TFA promotes apoptosis in tumor cells and induces reactive oxygen species (ROS) accumulation. It possesses anti-inflammatory and anti-angiogenic effects and is applicable in lung and colon cancer research.