PG-901

PG-901 is a full and selective MC5R agonist, exhibiting an EC50 of 0.072 nM for hMC5R. It also acts as a complete antagonist for hMC3R and hMC4R, with Kb values of 1.0 nM and 0.53 nM, respectively. Additionally, PG-901 significantly reduces the levels of cytokines (IL-1α, IL-1β, and IL-6), enhances glucose tolerance, lowers blood sugar, and mitigates retinal damage.