Epidermal mitosis inhibiting pentapeptide

Epidermalmitosisinhibiting pentapeptide, a pentapeptide, acts as a physiological inhibitor of epidermal cell proliferation. It notably reduces the DNA synthesis rate and mitotic rate of epidermal keratinocytes. In skin cancer models, it moderately enhances tumor formation but shows a stronger tendency to promote the regression of established tumors. It can be hydrolyzed by angiotensin-converting enzyme (ACE) and is applicable in cancer process research.