Tat-IKIP (46-60) TFA

Tat-IKIP (46-60) TFA is the trifluoroacetate salt form of Tat-IKIP (46-60), a transmembrane peptide targeting IκB kinase (IKK) . It inhibits IKK activation and NF-κB target gene expression by disrupting the IKKβ/NEMO complex. Tat-IKIP (46-60) significantly alleviates DSS-induced acute inflammation in a mouse model of inflammatory bowel disease (IBD) and reduces yeast polysaccharide-induced acute arthritis in an acute arthritis model (AAM) . This compound is applicable in the study of inflammatory diseases, such as IBD, pancreatitis, and rheumatoid arthritis.