Periplanetasin-4

Periplanetasin-4 is an antimicrobial peptide extracted from the American cockroach (Periplaneta americana) . It reduces cell rounding and apoptosis (apoptosis) and inhibits ROS production and downstream activation of p38 MAPK and p21 induced by Clostridium difficile toxin A. Periplanetasin-4 significantly increases mitochondrial calcium levels in Candida albicans ATCC 90028 cells, decreases DPH fluorescence intensity, and causes vacuole dysfunction. Additionally, it notably improves mucosal damage in mice intestines caused by toxin A. Periplanetasin-4 can be utilized for colitis research.