Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2 TFA

Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2 TFA is a bioactive peptide acting as a selective agonist for the protease-activated receptor 1 (PAR-1), demonstrating higher specificity for PAR-1 compared to PAR-2. PAR-1, part of the G protein-coupled receptor subfamily, is known to mediate cellular functions of thrombin. Beyond thrombin's various cellular roles, PAR-1 has been shown to interact with PAR-4, influencing thrombin-induced hepatocellular carcinoma, which forms thrombin in the tumor environment and is classified as "coagulation type."