Davalintide

Davalintide is an Amylin-mimetic peptide known for its high potency and extended action. It is a highly effective agonist of the amylin receptor (IC50 = 0.04 nM), calcitonin receptor (IC50 = 0.06 nM), and calcitonin gene-related peptide receptor [CGRP receptor] (IC50 = 3.1 nM) . Davalintide demonstrates greater efficacy than Amylin in cyclic adenosine monophosphate production through calcitonin receptor activation (EC50 = 1.4 nM) . It modulates blood glucose and body weight through mechanisms such as delaying gastric emptying, inhibiting glucagon secretion, and reducing food intake. Davalintide is utilized in research related to anti-obesity and antidiabetic treatments.