VMAPRTLFL

VMAPRTLFL is a 9-peptide derived from the HLA-G signal peptide and serves as a ligand for the HLA-E peptide. It plays a crucial role in regulating the function of adaptive natural killer (NK) cells. VMAPRTLFL specifically enriches FcεRγ-adaptive NK cells, upregulates CD25 expression, and enhances their proliferation, antibody-dependent cellular cytotoxicity (ADCC), and IFN-γ release. This peptide can be utilized in research related to human cytomegalovirus (HCMV) infection, transplant rejection, and pregnancy immunity.