Belumosudil (mesylate)

Belumosudil mesylate (KD025 mesylate) is a selective inhibitor of ROCK2 with IC50s of 105 nM and 24 μM for ROCK2 and ROCK1, respectively. Anti-fibrotic properties[1].

Product Specifications

CAS Number

[2109704-99-4]

Product Name Alternative

KD025 (mesylate) ; SLx-2119 (mesylate)

UNSPSC

12352005

Target

ROCK

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton; Stem Cell/Wnt; TGF-beta/Smad

Applications

COVID-19-anti-virus

Field of Research

Inflammation/Immunology; Cancer

Assay Protocol

https://www.medchemexpress.com/belumosudil-mesylate.html

Concentration

10mM

Purity

99.89

Solubility

DMSO : 10 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(NC(C)C)COC1=CC=CC(C2=NC(NC3=CC4=C(NN=C4)C=C3)=C5C=CC=CC5=N2)=C1.OS(=O)(C)=O

Molecular Formula

C27H28N6O5S

Molecular Weight

548.61

References & Citations

[1]Boerma, M., et al. Comparative gene expression profiling in three primary human cell lines after treatment with a novel inhibitor of Rho kinase. Blood Coagul Fibrinolysis. 2008 Oct;19 (7) :709-18.|[2]Lee, J.H., et al. Selective ROCK2 Inhibition In Focal Cerebral Ischemia. Ann Clin Transl Neurol. 2014 Jan 1;1 (1) :2-14.