Human TREM2 (19-157) Protein, Fc Tag
Triggering Receptor Expressed on Myeloid cells 2 (TREM2) is a pivotal cell-surface receptor primarily found on microglia in the brain and macrophages in peripheral tissues. Acting as a lipid and amyloid-beta sensor, it signals through the adapter protein DAP12 to regulate immune responses, cell survival, and phagocytosis. In neurobiology, TREM2 is a major focus because its dysfunction is strongly linked to Alzheimer’s disease progression and impaired clearance of neurotoxic plaques.
Product Specifications
Expression Region
His 19 - His 157
Reactivity
Human
Conjugation
Unconjugated
Tag
C-Fc
Field of Research
Neuroscience
Endotoxin
1.0 EU per μg
Purity
90%
Form
Powder
Molecular Weight
42.1 kDa
Storage Conditions
-20°C
Notes
For research use only.
Applications Notes
This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 42.1 kDa. The protein migrates as 50-55 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
NCBI Accession Number
Q9NZC2
Preservative
50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH 7.5
Available Sizes
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