Human Thrombopoietin / TPO Protein, Research Grade
Thrombopoietin (TPO) is a 332 amino acid glycoprotein made primarily in the liver and act as the major physiological regulator of platelet production. TPO binds the TPO receptor, activates JAK and STAT pathways, thus stimulating megakaryocyte growth and platelet production. Additionally, further investigation uncovered that thrombopoietin is a critical cytokine promoting hematopoietic rebound after myeloablation and its transcripts are expressed by multiple cellular sources.
Product Specifications
Expression Region
Ser 22 - Gly 353
Reactivity
Human
Conjugation
Unconjugated
Tag
Native
Endotoxin
0.01 EU per μg
Purity
95%
Form
Powder
Molecular Weight
35.5 kDa
Storage Conditions
-20°C
Notes
For research use only.
Applications Notes
This protein carries no "tag". The protein has a calculated MW of 35.5 kDa. The protein migrates as 75 kDa±5 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
NCBI Accession Number
P40225
Preservative
20 mM NaAc-HAc, pH 5.0
Available Sizes
Frequently Asked Questions
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