Heme Oxygenase-2-IN-1

Heme Oxygenase-2-IN-1 (Compound 9) is a potent, selective heme oxygenase-2 (HO-2) inhibitor with IC50 values of 0.9 μM and 14.9 μM against HO-2 and HO-1, respectively[1].

Product Specifications

CAS Number

[2994198-37-5]

UNSPSC

12352005

Target

Reactive Oxygen Species (ROS)

Type

Reference compound

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/heme-oxygenase-2-in-1.html

Purity

99.37

Solubility

DMSO : 83.33 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

N#CC1=CC=C(COC2=CC=C(C(O)CN3C=CN=C3)C=C2)C=C1

Molecular Formula

C19H17N3O2

Molecular Weight

319.36

References & Citations

[1]Floresta G, et al. Identification of a potent heme oxygenase-2 (HO-2) inhibitor by targeting the secondary hydrophobic pocket of the HO-2 western region. Bioorg Chem. 2020 Nov;104:104310.