Human LOX-1 Protein, His Tag (MALS verified)
LOX-1 is a transmembrane glycoprotein that binds to and internalizes ox-LDL.LOX-1 gene deletion in mice and anti-LOX-1 therapy has been shown to decrease inflammation, oxidative stress and atherosclerosis. LOX-1 deletion also results in damage from ischemia, making LOX-1 a promising target of therapy for atherosclerosis and related disorders. In this article we focus on the different mechanisms for regulation, signaling and the various effects of LOX-1 in contributing to atherosclerosis.
Product Specifications
Expression Region
Ser 61 - Gln 273
Reactivity
Human
Conjugation
Unconjugated
Tag
N-10xHis
Field of Research
Immunology & Inflammation
Endotoxin
0.05 EU per μg
Purity
90%
Form
Powder
Molecular Weight
26.4 kDa
Storage Conditions
-20°C
Notes
For research use only.
Applications Notes
This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 26.4 kDa. The protein migrates as 30-40 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
NCBI Accession Number
P78380
Preservative
PBS, pH 7.4
Available Sizes
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