Cynomolgus Integrin alpha X beta 2 (ITGAX&ITGB2) Heterodimer Protein, His Tag&Tag Free
The integrin αXβ2 takes a key role in host defense and functions as a receptor for the complement C3 cleavage product iC3b, fibrinogen, denatured proteins, and intercellular adhesion molecule (ICAM) -1. Integrin αXβ2 αXβ2 has a unique cellular distribution with expression on monocytes, macrophages, and the CD8− subsets of dendritic cells and involves in priming and regulation of the immune response.
Product Specifications
Expression Region
Phe 20 -Pro 1107 (ITGAX) & Gln 23 - Asn 700 (ITGB2)
Reactivity
Monkey
Conjugation
Unconjugated
Tag
C-10xHis | Native
Field of Research
Immunology & Inflammation
Endotoxin
1.0 EU per μg
Purity
90%
Form
Powder
Molecular Weight
125.9 kDa | 78.0 kDa
Storage Conditions
-20°C
Notes
For research use only.
Applications Notes
Cynomolgus ITGAX&ITGB2 Heterodimer Protein, His Tag&Tag Free, produced by co-expression of ITGAX and ITGB2, has a calculated MW of 125.9 kDa (ITGAX) and 78.0 kDa (ITGB2) . Subunit ITGAX is fused with an acidic tail at the C-terminus and followed by a polyhistidine tag and subunit ITGB2 contains no tag but a basic tail at the C-terminus. The protein migrates as 150-180 kDa (ITGAX) and 95-100 kDa (ITGB2) when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
NCBI Accession Number
ITGB2, XP_015298151.3, XP_065397351.1
Preservative
50 mM Tris, 150 mM NaCl, pH 7.5
Available Sizes
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