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Cynomolgus Integrin alpha 5 beta 1 (ITGA5&ITGB1) Heterodimer Protein, His Tag&Tag Free (MALS verified)

Integrin alpha 5 beta 1 / Integrin α5β1, which is a major cellular receptor for the extracellular matrix protein fibronectin and plays a fundamental role during mammalian development., is composed of α5 (ITGA5/CD49e) and β1 (ITGB1/CD29) subunits. Integrins are adhesion receptors that transmit bidirectional signals across the plasma membrane. The Integrin alpha 5 beta 1 and its primary extracellular matrix ligand fibronectin (Fn) are of great biological importance.

Product Specifications

Expression Region

Phe 42 - Tyr 999 (ITGA5) & Gln 161 - Asp 868 (ITGB1)

Reactivity

Monkey

Conjugation

Unconjugated

Tag

C-10xHis | Native

Field of Research

Immunology & Inflammation

Endotoxin

1.0 EU per μg

Purity

95%

Form

Powder

Molecular Weight

111.2 kDa (ITGA5) & 83.6 kDa (ITGB1)

Storage Conditions

-20°C

Notes

For research use only.

Applications Notes

Cynomolgus ITGA5&ITGB1 Heterodimer Protein, His Tag&Tag Free, produced by co-expression of ITGA5 and ITGB1, has a calculated MW of 111.2 kDa (ITGA5) & 83.6 kDa (ITGB1) . Subunit ITGA5 is fused with an acidic tail at the C-terminus and followed by a polyhistidine tag and subunit ITGB1 contains no tag but a basic tail at the C-terminus. The protein migrates as 130-160 kDa (ITGA5) and 95-110 kDa (ITGB1) when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (NR) condition (SDS-PAGE) due to glycosylation.

NCBI Accession Number

XP_005571144.3, ITGA5, ITGB1, A0A7N9D0D7

Preservative

50 mM HEPES, 150 mM NaCl, pH 7.5

Available Sizes

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