Mouse IL-7 R alpha&TSLP R Heterodimer Protein, Fc Tag&Fc Tag
TSLP is a pleiotropic cytokine originally characterized as a lymphocyte growth factor. Thymic stromal lymphopoietin (TSLP) is overexpressed in the airways of severe asthmatics and is an upstream cytokine that orchestrates inflammatory responses in asthma. Mouse TSLP exerts its biological activities by binding to a high-affinity heteromeric receptor complex composed of TSLPR and IL- 7 receptor and initiates signaling in cells co-expressing TSLPR and IL-7R.
Product Specifications
Expression Region
Glu 21 - Asp 239 (IL-7 RA) & Ala 20 - Pro 232 (TSLP R)
Reactivity
Mouse
Conjugation
Unconjugated
Tag
C-Fc | C-Fc
Field of Research
Immunology & Inflammation
Endotoxin
0.1 EU per μg
Purity
90%
Form
Powder
Molecular Weight
51.5 kDa (IL-7 RA) & 48.8 kDa (TSLP R)
Storage Conditions
-20°C
Notes
For research use only.
Applications Notes
Mouse IL-7 RA&TSLP R Heterodimer Protein, Fc Tag&Fc Tag is produced by co-expression of IL-7 RA and TSLP R, has a calculated MW of 51.5 kDa (IL-7 RA) & 48.8 kDa (TSLP R) . Subunit IL-7 RA is fused with a human IgG1 Fc fragment at the C-terminus and subunit TSLP R is fused with a human IgG1 Fc fragment at the C-terminus. The protein migrates as 55-65 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
NCBI Accession Number
P16872, Q8CII9
Preservative
PBS, pH 7.4
Available Sizes
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