Human GDNF / ATF / hGDNF Protein (E. coli), Research Grade
Glial cell line-derived neurotrophic factor (GDNF) is a neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake. GDNF is a glycosylated, disulfide-bonded homodimer that is a distantly related member of the transforming growth factor-beta superfamily. The GDNF family members (consists of GDNF, neurturin, artemin and persephin) are structurally similar to transforming growth factor-beta. Unlike other members of the TGF-beta superfamily, which signal through the receptor serine-threonine kinases, GDNF family ligands activate intracellular signalling cascades via the receptor tyrosine kinase Ret. GDNF family ligands binds to GDNF family receptor alpha (GFRalpha) and then the GDNF family ligand-GFR alpha complex binds to and stimulates autophosphorylation of Ret.
Product Specifications
Expression Region
Ser 78 - Ile 211
Reactivity
Human
Conjugation
Unconjugated
Tag
Native
Field of Research
Infectious Disease & Virology
Endotoxin
0.01 EU per μg
Purity
95%
Form
Powder
Molecular Weight
15.2 kDa
Storage Conditions
-20°C
Notes
For research use only.
Applications Notes
NCBI Accession Number
P39905
Preservative
20 mM Sodium Citrate, 150 mM NaCl, pH 4.0
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
CD59 (heavy chain of Protectin) (BRA-10G), CF594 conjugate, 0.1mg/mL
Eosinophil Peroxidase (AHE-1), CF405S conjugate, 0.1mg/mL
TAG-72 / CA72.4 (B72.3), CF740 conjugate, 0.1mg/mL
