MitoBloCK-6

MitoBloCK-6 is a potent Erv1/ALR inhibitor, with an IC50 of 900 nM and 700 nM, respectively. MitoBloCK-6 also inhibits Erv2 (IC50=1.4 μM) . MitoBloCK-6 can induce Apoptosis via cytochrome c release. MitoBloCK-6 inhibits growth of developing zebrafish motor neurons. MitoBloCK-6 has anticancer activity against liver cancer and leukemia[1][2][3][4][5][6].

Product Specifications

CAS Number

[303215-67-0]

UNSPSC

12352005

Target

Aldose Reductase; Apoptosis

Type

Reference compound

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/mitoblock-6.html

Purity

98.07

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

OC1=C(/C=N/C2=CC=C(NC3=CC=CC=C3)C=C2)C=C(Cl)C=C1Cl

Molecular Formula

C19H14Cl2N2O

Molecular Weight

357.23

References & Citations

[1]Dabir DV, et, al. A small molecule inhibitor of redox-regulated protein translocation into mitochondria. Dev Cell. 2013 Apr 15;25 (1) :81-92. |[2]Kabiri Y, et al. Mitochondrial Impairment by MitoBloCK-6 Inhibits Liver Cancer Cell Proliferation. Front Cell Dev Biol. 2021 Sep 20;9:725474.|[3]Jeyaraju D V, et al. Inhibition of the mitochondrial protein import machinery is selectively cytotoxic to acute myeloid leukemia (AML) cells and stem cells. Blood, 2016, 128 (22) : 1572.|[4]Singh RP, et al. Disrupting Mitochondrial Copper Distribution Inhibits Leukemic Stem Cell Self-Renewal. Cell Stem Cell. 2020 Jun 4;26 (6) :926-937.e10.|[5]Johnson M E. One Fish, Two Fish, Small Fish, Huge Fish: Utilizing Zebrafish as a Model for Studying Mitochondrial Function. UCLA, 2012.|[6]Jeyaraju D V, et al. Inhibiting the Mitochondrial Sulfhydryl Oxidase Alr Reduces Cox17 and Alters Mitochondrial Cristae Structure Leading to the Differentiation of AML and Stem Cells. 2017.