PEG3-C4-OBn
PEG3-C4-OBn is a polyethylene glycol (PEG) -based PROTAC linker. PEG3-C4-OBn can be used in the synthesis of the PROTAC SGK3 degrader-1 (HY-125878) . PROTAC SGK3 degrader-1 is a potent SKG3 degrader based on PROTAC[1][2].
Product Specifications
CAS Number
[2381196-79-6]
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
PROTAC Linkers
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/peg3-c4-obn.html
Purity
99.29
Solubility
DMSO : ≥ 100 mg/mL
Smiles
OCCOCCOCCCCCCOCC1=CC=CC=C1
Molecular Formula
C17H28O4
Molecular Weight
296.41
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
References & Citations
[1]Tovell H, et al. Design and Characterization of SGK3-PROTAC1, an Isoform Specific SGK3 Kinase PROTAC Degrader. ACS Chem Biol. 2019 Sep 20;14 (9) :2024-2034.|[2]Tovell H, et al. Design and Characterization of SGK3-PROTAC1, an Isoform Specific SGK3 Kinase PROTAC Degrader. ACS Chem Biol. 2019 Sep 5.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PEG Linkers
Available Sizes
Curated Selection
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