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Dorzagliatin (Standard)

Dorzagliatin (Standard) is the analytical standard of Dorzagliatin. This product is intended for research and analytical applications. Dorzagliatin (HMS5552), a dual-acting glucokinase (GK) activator, improves glycaemic control and pancreatic β-cell function in type 2 diabetes[1].

Product Specifications

CAS Number

[1191995-00-2]

Product Name Alternative

HMS5552 (Standard)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Glucokinase; Reference Standards

Type

Reference Standards

Related Pathways

Metabolic Enzyme/Protease; Others

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/dorzagliatin-standard.html

Purity

98.47

Smiles

O=C([C@H](CC(C)C)N1CC(OC2=C(Cl)C=CC=C2)=CC1=O)NC3=NN(C=C3)C[C@H](CO)O

Molecular Formula

C22H27ClN4O5

Molecular Weight

462.93

Precautions

H302, H315, H319, H335

References & Citations

[1]Zhu XX, et al. Dorzagliatin (HMS5552), a novel dual-acting glucokinase activator, improves glycaemic control and pancreatic β-cell function in patients with type 2 diabetes: A 28-day treatment study using biomarker-guided patient selection. Diabetes Obes Metab. 2018 Sep;20 (9) :2113-2120.|[2]Wang P, et al. Effects of a Novel Glucokinase Activator, HMS5552, on Glucose Metabolism in a Rat Model of Type 2 Diabetes Mellitus. J Diabetes Res. 2017;2017:5812607.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, sealed storage, away from light and moisture

Scientific Category

Reference Standards

Clinical Information

No Development Reported

Available Sizes

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