Cyano-myracrylamide
Cyano-myracrylamide is an inhibitor of zinc finger DHHC domain-containing palmitoyltransferase 20 (zDHHC20) with an IC50 value of 1.35 µM. Cyano-myracrylamide also inhibits the S-Acylation of EGFR and CD36. Cyano-myracrylamide also inhibits S-acylation of Legionella E3 ligase GobX, MyD88, and Ras, which are substrates of zDHHC20, zDHHC9, and zDHHC6, respectively, in HEK293T cells expressing recombinant Legionella GobX, recombinant human MyD88, or endogenous Ras[1].
Product Specifications
CAS Number
[2801702-34-9]
UNSPSC
12352211
Target
Acyltransferase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/cyano-myracrylamide.html
Purity
98.13
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
N#CCN(CCCCCCCCCCCCCC)C(C=C)=O
Molecular Formula
C19H34N2O
Molecular Weight
306.49
References & Citations
[1]Azizi SA, et al. Development of an Acrylamide-Based Inhibitor of Protein S-Acylation. ACS Chem Biol. 2021 Aug 20;16 (8) :1546-1556.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Available Sizes
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