MMV390048
MMV390048 is a representative of a new chemical class of Plasmodium PI4K inhibitor (Kdapp=0.3 μM) . MMV390048 binds to the ATP binding site of Plasmodium PI4K and does not bind to other P. falciparum and human kinases apart from human PIP4K2C, thus alleviating potential kinase-mediated safety concerns. MMV390048 is an antimalarial agent[1].
Product Specifications
CAS Number
[1314883-11-8]
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Parasite; PI4K
Type
Reference compound
Related Pathways
Anti-infection; PI3K/Akt/mTOR
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/mmv390048.html
Purity
98.85
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
NC1=NC=C(C2=CC=C(S(=O)(C)=O)C=C2)C=C1C3=CC=C(C(F)(F)F)N=C3
Molecular Formula
C18H14F3N3O2S
Molecular Weight
393.38
Precautions
H302, H315, H319
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
Plasmodium
Available Sizes
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