MMV390048

MMV390048 is a representative of a new chemical class of Plasmodium PI4K inhibitor (Kdapp=0.3 μM) . MMV390048 binds to the ATP binding site of Plasmodium PI4K and does not bind to other P. falciparum and human kinases apart from human PIP4K2C, thus alleviating potential kinase-mediated safety concerns. MMV390048 is an antimalarial agent[1].

Product Specifications

CAS Number

[1314883-11-8]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

Parasite; PI4K

Type

Reference compound

Related Pathways

Anti-infection; PI3K/Akt/mTOR

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/mmv390048.html

Purity

98.85

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

NC1=NC=C(C2=CC=C(S(=O)(C)=O)C=C2)C=C1C3=CC=C(C(F)(F)F)N=C3

Molecular Formula

C18H14F3N3O2S

Molecular Weight

393.38

Precautions

H302, H315, H319

References & Citations

[1]Paquet T, et al. Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase. Sci Transl Med. 2017 Apr 26;9 (387) . pii: eaad9735.