DMH2
DMH2 is a potent BMP receptor antagonist. DMH2 downregulates the expression of Id1 and Id3 proteins, and inhibits the proliferation and induces cell death of lung cancer cell lines[1].
Product Specifications
CAS Number
[1206711-14-9]
Product Name Alternative
VU364849
UNSPSC
12352005
Target
Apoptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dmh2.html
Purity
99.6
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
C1(C2=C3N=CC(C4=CC=C(OCCN5CCOCC5)C=C4)=CN3N=C2)=C6C=CC=CC6=NC=C1
Molecular Formula
C27H25N5O2
Molecular Weight
451.52
References & Citations
[1]Langenfeld J E, Langenfeld E. Src inhibition enhances BMP receptor antagonists downregulation of Id1 and growth suppression of lung cancer cells with a K-Ras mutation. 2013:5263.|[2]Tsugawa D, Oya Y, Masuzaki R, et al. Specific activin receptor-like kinase 3 inhibitors enhance liver regeneration. J Pharmacol Exp Ther. 2014;351 (3) :549-558.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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