RepSox (GMP)
RepSox (E-616452) (GMP) is a RepSox produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. RepSox is a potent and selective TGF-β-RI/ALK5 inhibitor[1].
Product Specifications
CAS Number
446859-33-2
Product Name Alternative
E-616452 (GMP) ; SJN 2511 (GMP)
UNSPSC
12352005
Hazard Statement
H301
Target
TGF-β Receptor
Type
GMP Small Molecules
Related Pathways
TGF-beta/Smad
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/repsox-gmp.html
Purity
99.0
Solubility
10 mM in DMSO
Smiles
CC1=NC(C2=NNC=C2C3=NC4=CC=CN=C4C=C3)=CC=C1
Molecular Formula
C17H13N5
Molecular Weight
287.32
Precautions
H301
References & Citations
[1]Zhao T, et al. Single-Cell RNA-Seq Reveals Dynamic Early Embryonic-like Programs during Chemical Reprogramming. Cell Stem Cell. 2018 Jul 5;23 (1) :31-45.e7. |[2]Guan J, et al. Chemical reprogramming of human somatic cells to pluripotent stem cells. Nature. 2022 May;605 (7909) :325-331. |[3]Bar-Nur O, et al. Direct Reprogramming of Mouse Fibroblasts into Functional Skeletal Muscle Progenitors. Stem Cell Reports. 2018 May 8;10 (5) :1505-1521.
Shipping Conditions
Blue Ice
Storage Conditions
4°C, sealed storage, away from moisture and light
Scientific Category
GMP Small Molecules
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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