RepSox (GMP)

RepSox (E-616452) (GMP) is a RepSox (HY-13012) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. RepSox is a potent and selective TGF-β-RI/ALK5 inhibitor[1].

Product Specifications

CAS Number

[446859-33-2]

Product Name Alternative

E-616452 (GMP) ; SJN 2511 (GMP)

UNSPSC

12352005

Hazard Statement

H301

Target

TGF-β Receptor

Type

GMP Small Molecules

Related Pathways

TGF-beta/Smad

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/repsox-gmp.html

Purity

99.0

Solubility

10 mM in DMSO

Smiles

CC1=NC(C2=NNC=C2C3=NC4=CC=CN=C4C=C3)=CC=C1

Molecular Formula

C17H13N5

Molecular Weight

287.32

Precautions

H301

References & Citations

[1]Zhao T, et al. Single-Cell RNA-Seq Reveals Dynamic Early Embryonic-like Programs during Chemical Reprogramming. Cell Stem Cell. 2018 Jul 5;23 (1) :31-45.e7. |[2]Guan J, et al. Chemical reprogramming of human somatic cells to pluripotent stem cells. Nature. 2022 May;605 (7909) :325-331. |[3]Bar-Nur O, et al. Direct Reprogramming of Mouse Fibroblasts into Functional Skeletal Muscle Progenitors. Stem Cell Reports. 2018 May 8;10 (5) :1505-1521.