Argatroban

Argatroban (MD-805) is a direct, selective thrombin inhibitor.

Product Specifications

CAS Number

[74863-84-6]

Product Name Alternative

MD-805; MCI-9038

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Thrombin

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/argatroban.html

Purity

99.88

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C([C@@H]1N(C([C@@H](NS(=O)(C2=CC=CC3=C2NCC(C)C3)=O)CCCNC(N)=N)=O)CC[C@@H](C)C1)O

Molecular Formula

C23H36N6O5S

Molecular Weight

508.63

Precautions

H302, H315, H319, H335

References & Citations

[1]Kawada, T., et al., Argatroban, an attractive anticoagulant, for left heart bypass with centrifugal pump for repair of traumatic aortic rupture. Jpn J Thorac Cardiovasc Surg, 1999. 47 (3) : p. 104-9.|[2]Jang, I.K., et al., A multicenter, randomized study of argatroban versus heparin as adjunct to tissue plasminogen activator (TPA) in acute myocardial infarction: myocardial infarction with novastan and TPA (MINT) study. J Am Coll Cardiol, 1999. 33 (7) : p. 1879-85.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light)

Scientific Category

Reference compound1

Clinical Information

Launched

Citation 01

Biomed Pharmacother. 2025 Apr 28:187:118104.|Int Immunopharmacol. 2025 Apr 4:151:114334.|Int J Mol Sci. 2021 Mar 24;22 (7) :3323.|University of Bonn. 2023 May 31.|Antiviral Res. 2023 Jun:214:105606.