WYC-209
WYC-209, a synthetic retinoid, is a retinoic acid receptor (RAR) agonist. WYC-209 induces apoptosis primarily via the caspase 3 pathway (IC50=0.19 μM for inmalignant murine melanoma TRCs), and has long-term effects with little toxicity[1].
Product Specifications
CAS Number
[2131803-90-0]
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Apoptosis; Autophagy; RAR/RXR
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Neuroscience-Neurodegeneration
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/wyc-209.html
Purity
99.82
Solubility
DMSO : 83.33 mg/mL (ultrasonic)
Smiles
O=C(C1=CN=C(C#CC2=CC=C3C(C(C)(C)CCS3=O)=C2)N=C1)OCC
Molecular Formula
C20H20N2O3S
Molecular Weight
368.45
Precautions
H302, H315, H319
References & Citations
[1]Chen J, et al. Inhibition of cancer stem cell like cells by a synthetic retinoid. Nat Commun. 2018 Apr 11;9 (1) :1406.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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