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Anti-Human/Mouse denatured collagen type-I Antibody (XL313)

Selected Variant

HY-P990251-01

Size: 1 mg

Anti-Human/Mouse denatured collagen type-I Antibody (XL313) is a mouse-derived IgG1 κ type antibody inhibitor, targeting to human/mouse denatured collagen type-I. Anti-Human/Mouse denatured collagen type-I Antibody (XL313) selectively binds to proteolyzed collagen type I. Anti-Human/Mouse denatured collagen type-I Antibody (XL313) reduces PD L1 levels in tumor cells. Anti-Human/Mouse denatured collagen type-I Antibody (XL313) can be used for the researches of cancer and inflammation, such as such as ovarian tumor[1][2][3].

Product Specifications

CAS Number

9007-83-4

UNSPSC

12352203

Target

Collagen; MMP; PD-1/PD-L1

Type

Inhibitory Antibodies

Related Pathways

Cytoskeleton; Immunology/Inflammation; Metabolic Enzyme/Protease

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/anti-human-mouse-denatured-collagen-type-i-antibody-xl313.html

Purity

95

Solubility

10 mM in DMSO

Smiles

[Anti-Human/Mousedenaturedcollagentype-IAntibody(XL313)]

Molecular Weight

(150 kDa)

References & Citations

[1]Ames JJ, et al. Identification of an Endogenously Generated Cryptic Collagen Epitope (XL313) That May Selectively Regulate Angiogenesis by an Integrin Yes-associated Protein (YAP) Mechano-transduction Pathway. J Biol Chem. 2016 Feb 5;291 (6) :2731-50. |[2]Caron JM, et al. Targeting the secreted RGDKGE collagen fragment reduces PD‑L1 by a proteasome‑dependent mechanism and inhibits tumor growth. Oncol Rep. 2023 Feb;49 (2) :44. |[3]Brooks, et al. Reversing Immunotherapy Resistance in Ovarian Cancer by Targeting a Novel Immune-Suppressive Factor Released by Tumor-Associated Macrophages (TAMs) . Technical Report,15 Apr 2017,14 Apr 2020.

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4°C for 2 years, do not freeze

Scientific Category

Inhibitory Antibodies

Clinical Information

No Development Reported

Available Sizes

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