IRAK1/4/pan-FLT3 Kinase-IN-1

IRAK1/4/pan-FLT3 Kinase-IN-1 (Compound 31) is a potent inhibitor of IRAK1, IRAK4, and FLT3 kinases, with an IC50 of 5 nM for IRAK1, 0.6 nM for IRAK4, and less than 0.5 nM for FLT3. IRAK1/4/pan-FLT3 Kinase-IN-1 has good pharmacokinetic properties and shows promising potential for research in acute myeloid leukemia, with a survival prolongation effect comparable to that of Gilteritinib (HY-12432) [1].

Product Specifications

CAS Number

[2760328-82-1]

UNSPSC

12352005

Target

FLT3; IRAK

Type

Reference compound

Related Pathways

Immunology/Inflammation; Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/irak1-4-pan-flt3-kinase-in-1.html

Purity

99.25

Solubility

DMSO : 5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

CC(O)(C1=CN2C(C=C1OC)=NC=C2C3=NC(N[C@H]4CNCC[C@@H]4F)=CC=C3)C

Molecular Formula

C21H26FN5O2

Molecular Weight

399.46

References & Citations

[1]Hoyt SB, et al. Discovery of IRAK1/4/pan-FLT3 Kinase Inhibitors as Treatments for Acute Myeloid Leukemia. ACS Med Chem Lett. 2024 Oct 23;15 (11) :1843-1851.