Nitrosoglutathione

Nitrosoglutathione (GSNO), a exogenous NO donor and a substrate for rat alcohol dehydrogenase class III isoenzyme, inhibits cerebrovascular angiotensin II-dependent and -independent AT1 receptor responses[1][2][3][4].

Product Specifications

CAS Number

[57564-91-7]

Product Name Alternative

GSNO; RVC-588; S-Nitroso-L-glutathione

UNSPSC

12171500

Hazard Statement

H301, H311, H331

Target

Angiotensin Receptor; Endogenous Metabolite

Type

Dye Reagents

Related Pathways

GPCR/G Protein; Metabolic Enzyme/Protease

Field of Research

Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/nitrosoglutathione.html

Purity

90.56

Solubility

H2O : 25 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

OC(CNC([C@H](CSN=O)NC(CC[C@H](N)C(O)=O)=O)=O)=O

Molecular Formula

C10H16N4O7S

Molecular Weight

336.32

Precautions

H301, H311, H331

References & Citations

[1]Marie-Lynda Bouressam, et al. S-nitrosoglutathione inhibits cerebrovascular angiotensin II-dependent and -independent AT 1 receptor responses: A possible role of S-nitrosation. Br J Pharmacol. 2019 Jun;176 (12) :2049-2062.|[2]D E Jensen, et al. S-Nitrosoglutathione is a substrate for rat alcohol dehydrogenase class III isoenzyme. Biochem J. 1998 Apr 15;331 (Pt 2) (Pt 2) :659-68.|[3]Caneta Brown, et al. The effects of S-nitrosoglutathione and S-nitroso-N-acetyl-D, L-penicillamine in a rat model of pre-eclampsia. J Nat Sci Biol Med. 2013 Jul;4 (2) :330-5.|[4]Yur-Ren Kuo, et al. Nitrosoglutathione promotes flap survival via suppression of reperfusion injury-induced superoxide and inducible nitric oxide synthase induction. J Trauma. 2004 Nov;57 (5) :1025-31.|[5]Eva Nozik-Grayck, et al. Pulmonary vasoconstriction by serotonin is inhibited by S-nitrosoglutathione. Am J Physiol Lung Cell Mol Physiol. 2002 May;282 (5) :L1057-65.