Isosaponarin

Isosaponarin is a flavone glycoside isolated from wasabi leaves. Isosaponarin is a P4HA2 enzymatic agonist. Isosaponarin increases collagen synthesis via up-regulated TGF-β type II receptor (TβR-II) and prolyl 4-hydroxylase (P4H) proteins production, promoting skin health and wound healing. Isosaponarin-rich plants exhibit strong antimicrobial, antioxidant, anti-hyaluronidase, antiplatelet, anti-atopic dermatitis, and anti-tumor effects[1][2][3][4][5].

Product Specifications

CAS Number

[19416-87-6]

UNSPSC

12352005

Target

Collagen; TGF-β Receptor

Type

Natural Products

Related Pathways

Cytoskeleton; TGF-beta/Smad

Applications

Cancer-Kinase/protease

Field of Research

Cancer; Infection; Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/isosaponarin.html

Purity

99.59

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C1C=C(C2=CC=C(O[C@H]3[C@@H]([C@H]([C@@H]([C@@H](CO)O3)O)O)O)C=C2)OC4=CC(O)=C([C@H]5[C@@H]([C@H]([C@@H]([C@@H](CO)O5)O)O)O)C(O)=C14

Molecular Formula

C27H30O15

Molecular Weight

594.52

References & Citations

[1]Masashi Nagai, et al. The effect of isosaponarin isolated from wasabi leaf on collagen synthesis in human fibroblasts and its underlying mechanism. J Nat Med. 2010 Jul;64 (3) :305-12.|[2]Lu CW, et al. The Effect of Isosaponarin Derived from Wasabi Leaves on Glutamate Release in Rat Synaptosomes and Its Underlying Mechanism. Int J Mol Sci. 2022 Aug 6;23 (15) :8752.|[3]Kaynat Firdos et al. Harnessing isosaponarin: A multifaceted bioactive and therapeutic potential compound from nature. Biol. Biomed. J. (2025) Vol. 3, Issue (2) Pages 1-12.|[4]Chi Z, et al. P4HA2 promotes proliferation, invasion, and metastasis through regulation of the PI3K/AKT signaling pathway in oral squamous cell carcinoma. Sci Rep. 2024 Jul 1;14 (1) :15023.|[5]Hashimoto, et al. Dietary Isosaponarin is Intestinally Metabolized to Isovitexin, Most of Which are Excreted in Feces without Being Absorbed. Asian Journal of Food Research and Nutrition,2 (3) :104-116.